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Antimicrobial polymer
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Antimicrobial polymer : ウィキペディア英語版
Antimicrobial polymer
Antimicrobial polymers, also known as polymeric biocides, is a class of polymers with antimicrobial activity, or the ability to inhibit the growth of microorganisms such as bacteria, fungi or protozoans. These polymers have been engineered to mimic antimicrobial peptides which are used by the immune systems of living things to kill bacteria. Typically, antimicrobial polymers are produced by attaching or inserting an active antimicrobial agent onto a polymer backbone via an alkyl or acetyl linker. Antimicrobial polymers may enhance the efficiency and selectivity of currently used antimicrobial agents, while decreasing associated environmental hazards because antimicrobial polymers are generally nonvolatile and chemically stable. This makes this material a prime candidate for use in areas of medicine as a means to fight infection, in the food industry to prevent bacterial contamination, and in water sanitation to inhibit the growth of microorganisms in drinking water.
== How do antimicrobial agents kill bacteria? ==
Antimicrobial agents kill bacteria through different methods depending on the type of bacteria. Most antiseptics and disinfectants kill bacteria immediately on contact by causing the bacterial cell to burst, or by depleting the bacteria's source of food preventing bacterial reproduction, also known as bacterial conjugation. Antimicrobial polymers commonly kill bacteria through this first method, which is accomplished through a series of steps, shown in Figure 1. First, the polymer must adsorb onto the bacterial cell wall. Most bacterial surfaces are negatively charged, therefore the adsorption of polymeric cations has proved to be more effective than adsorption of polymeric anions. The antimicrobial agent must then diffuse through the cell wall and adsorb onto the cytoplasmic membrane. Small molecule antimicrobial agents excel at the diffusion step due to their low molecular weight, while adsorption is better achieved by antimicrobial polymers. The disruption of the cytoplasmic membrane and subsequent leakage of cytoplasmic constituents leads to the death of the cell. Comparison of small molecule antimicrobial agents and antimicrobial polymers are shown in the following table:〔


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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